Phosphatidylserine is a phospholipid that is classified as a polar ionic compound. Like phosphatidylcholine, it too is made of an alcohol and a diacylglycerol, or sphingosine, linked by a phosphodiester bridge. [1] Phosphatidylserine is synthesized in the body primarily via exchange of ethanolamine, from phosphatidylethanolamine, for serine. [2] Biosynthesis also requires adequate levels of folic acid, vitamin B12, and essential fatty acids.

Phosphatidylserine is a vital component of cell membranes and is the major acidic phospholipid in the brain. [2] Its fluid nature, which is necessary for cell to cell communication and cellular metabolism, underscores the importance of this compound in cell membrane function and integrity.

This phospholipid has broad effects in the central nervous system. Administering preparations of phosphatidylserine to aged rats has increased dopamine release in the striatum, stimulated acetylcholine secretion, and has prevented age-related atrophy of cholinergic cells in the basal forebrain. [3] Phosphatidylserine supplementation has demonstrated changes in EEG activity in humans. [4] As well, taking PS over a period of 30 days has restored the circadian rhythmicity of thyroid-stimulating hormone (TSH) secretion in hospitalized patients. [5]

Products Containing Phosphatidylserine
Name Price Rating Serving Price # of Servings Manufacturer Health Condition
Animal Cuts Free $28.59
$28.59 1 Universal Nutrition Obesity
Attend $35.05
$0.58 60 Vaxa ADHD
Cyntol $29.95
$1.00 30 Progressive Health
EndoRush Fruit Punch $39.99
$2.67 15 BSN
Gingko $11.07
$0.37 30 Apex
Listol $54.95
$1.83 30 Progressive Health ADHD
Progressive-17 $34.95
$1.17 30 Progressive Health


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