CLA (from CLA oil)

Conjugated linoleic acid (CLA) is not a single substance. However, it is classified as an omega-6 essential fatty acid, existing as an isomer of linoleic acid. The structure of CLA is very similar to that of linoleic acid, except that it has two double bonds separated by a single bond. Because Conjugated linoleic acid has two double bonds, it is able to have several different isomers. The most important isomers include; cis-9, cis-12, trans-10, and the trans-11 isomers. The formation of each isomer is dependant upon the location of the double bonds and the relationship in the space of the arranged molecules.

Conjugated linoleic acid is produced naturally in the rumen of animals by the bacterial metabolism of both linoleic and linolenic acids. Animal sources and dairy products represent the greatest source of conjugated linoleic acid. Gamma-linolenic acid (GLA) is an Omega-3 essential fatty acid that is found in the fatty acid fraction of some plant seed oils, including those of flax, borage, and hemp. GLA may provide certain antithrombotic and anti-inflammatory actions.

Conjugated linoleic acid is readily absorbed by the small intestine. Its exact mechanism of action is not clearly understood. Being a fatty acid, it may have a role in the prostaglandin pathways similar to other fatty acids.

Most of what is known about Conjugated linoleic acid comes from in vivo animal and in vitro studies. Because of the promising results yielded by such studies, human research is currently being carried out. These trials will be able to provide more concrete information about the mechanisms of action regarding CLA, within the human body.

To date, Conjugated linoleic acid is believed to possess anti-carcinogenic activity. It has shown benefit for breast, colon, prostate, lung, and melanoma cancers. [1] It has been equally effective as a modulator of carcinogenesis at the stages of initiation, promotion, and progression. Conjugated linoleic acid also has the ability to cause or promote cell death (apoptosis).

Conjugated linoleic acid is also thought to possess certain anti-diabetic and anti-atherogenic properties. This nutrient may also be able to decrease the total percentage of body fat, while promoting increases in lean muscle mass.

Conjugated linoleic acid may provide an effective, adjunctive treatment for certain cancers, diabetes, cardiovascular disease, and obesity.

Products Containing CLA (from CLA oil)
Name Price Rating Serving Price # of Servings Manufacturer Health Condition
Lipitrex $74.95
$2.50 30 Progressive Health Obesity


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