Alpha Lipoic Acid

Alpha lipoic acid is useful for a variety of conditions. It is effective as therapy for diabetes, cardiovascular disease, HIV, and is considered a metal chelator. It may be helpful for neurodegenerative disease and has some practicality in cataract and glaucoma treatment. Alpha lipoic acid was once thought to be an essential vitamin for humans and animals. It was then discovered that humans produced it endogenously. Therefore it is not an essential nutrient.

In nature, alpha lipoic acid exists in two entantiomers (forms): the or the (s) entantiomer. The is the natural and most active form. Supplements of alpha lipoic acid contain a 50/50 ratio of the two forms.[1]

Alpha lipoic acid is absorbed within the small intestine. The natural or form is more absorbed than the (s) form. In the body it is reduced to dihydrolipoic acid (DHLA), which works together with alpha lipoic acid.

The endogenous production of alpha lipoic acid serves as a cofactor for two reactions involved in energy production of the Kreb's cycle. It is a cofactor for the enzymes pyruvate dehydrogenase and alpha ketoglutarate dehydrogenase. Each of these reactions is carried out in the mitochondria. It also enhances energy production by the mitochondria in various tissues throughout the body. Alpha lipoic acid also serves as a cofactor for the production of the branched chain amino acids leucine, isoleucine, and valine.

In the 1980's, the high antioxidant potential of alpha lipoic acid was discovered. Endogenous production does not supply the body enough to give alpha lipoic acid its antioxidant activity, therefore supplementation is necessary for any effects past those of a cofactor in metabolic reactions. As an antioxidant, alpha lipoic acid scavenges free radicals. It works as a redox pair with DHLA, its reduced form, to fulfill this scavenging action. Both contain the ability to scavenge hydroxyl radicals, nitric oxide radicals, peroxynitrite, hydrogen peroxide, and hypochorite. Alpha lipoic acid alone can scavenge single oxygen; DHLA can scavenge superoxide and peroxyl reactive oxygen species.

Alpha lipoic acid is considered among the universal antioxidants, because it is both water and lipid soluble. It is for this characteristic that alpha lipoic acid is beneficial for conditions that occur in the cellular environment, as well as inside the cell and cell membrane. Another point that makes alpha lipoic acid unique is that it can pass the blood brain barrier, allowing for its antioxidant capabilities to be utilized by the CNS.

Alpha lipoic acid also serves as an antioxidant-recycling molecule. It is involved in the regeneration of Glutathione, Coenzyme Q10, Vitamin C, Vitamin E, and Vitamin A.

Products Containing Alpha Lipoic Acid
Name Price Rating Serving Price # of Servings Manufacturer Health Condition
7 Day Acne Detox $49.99
$1.79 28 Acne
Acnepril $27.99
$0.47 60 Acne
Acneticin $39.95
$1.33 30 Acneticin Acne
Acnezine Skin Antioxidant $29.95
$0.00 0 Revitol Acne
Animal Cuts Free $28.59
$28.59 1 Universal Nutrition Obesity
Anistil $28.95
$1.93 15 Progressive Health
Balance Point for Men $29.95
$1.00 30 Progressive Health
Balance Point for Women $35.95
$1.20 30 Progressive Health
Callumae $45.95
$1.53 30 Progressive Health Vitiligo
Emergen-C $9.15
$0.25 36 Alacer
Glucose M2 $26.95
$0.90 30 Progressive Health
Leptodrene $29.99
$0.00 0 Acne
Mens Super Vites $11.90
$0.26 45 Heaven & Earth
Opti-Women $22.39
$0.37 60 Optimum Nutrition
Orovo Acne $44.95
$0.75 60 Orovo LLC Acne
Oxynox $34.95
$1.17 30 Progressive Health Emphysema
Pro Complex Gainer $33.99
$2.43 14 Optimum Nutrition
Revitle $27.00
$0.90 30 Progressive Health Aging
Super Anti Oxidant $11.72
$0.39 30 Apex
Taraxatone $19.24
$0.96 20 Cytodyne
Vilantae $38.50
$0.10 400 GMP Certified Laboratory Acne
Visulyn $59.95
$2.00 30 Progressive Health Vision
Womens Super Vites $11.99
$0.27 45 Heaven & Earth


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