Acetyl L-Carnitine HCI

Acetyl-L-carnitine is a naturally formed derivative of the biochemical compound carnitine, and actively participates in the ?-oxidation of fatty acids. The major pathway whereby saturated fatty acids are catabolized occurs in the mitochondria of cells. In order for a saturated fatty acid to be catabolized, it must first enter the cell, get converted to a CoA derivative and then be transported across the inner membrane of the mitochondria. This membrane is, largely, impermeable to bulky polar molecules. This is where carnitine plays an integral role.


Carnitine serves as a specialized carrier in the mitochondrial inner membrane, transporting fatty acids which have undergone a CoA derivative conversion. This transport process is referred to as the “carnitine shuttle.” Once fatty acids are inside the mitochondria, two carbon fragments are removed from the carboxyl end of the fatty acid, thus producing acetyl CoA.


Ultimately, the importance of the carnitine shuttle lies in allowing cells to use long chain fatty acids as a fuel source. Especially in muscle, these fatty acids can be used for energy. By utilizing fatty acids for energy, fatty build up is prevented in organs such as the heart and liver. Assisting the heart with oxygen consumption efficacy, carnitine provides for improved functioning of the cardiac component. This positively affects conditions such as angina, arrhythmias, heart attack recovery, and congestive heart failure.


Carnitine also plays an important role in fat metabolism, which appears to reduce the risk of damage in conditions like diabetes, alcohol-induced fatty liver, and cardiovascular disease. Many specific functions are associated with the carnitine administration, including; decreasing high cholesterol levels, assisting with weight loss, improving muscle strength in musculoskeletal disorders, addressing immune system dysfunction, positively impacting mental function and improving sperm count and motility. Carnitine also protects against oxidative stress, enhances antioxidant activity of some enzymes, and helps to regulate hormonal changes caused by physical stress.


Carnitine is made from the essential amino acids methionine and lysine. Acetyl-L-carnitine, on the other hand, is a derivitave of carnitine (acetic acid is bound to carnitine). Acetyl-L-Carnitine has been widely researched, especially within the treatment of Alzheimer's disease. This form of carnitine structurally resembles acetylcholine, an important neurotransmitter in the brain, and actually mimics some of the actions. It appears that this form of carnitine is more effective in treating conditions of the brain, than carnitine alone.



Products Containing Acetyl L-Carnitine HCI
Name Price Rating Serving Price # of Servings Manufacturer Health Condition
Cyntol $29.95
 
(0)
$1.00 30 Progressive Health
Progressive-17 $34.95
 
(1)
$1.17 30 Progressive Health

 

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