Restless Leg Syndrome Treatment   If Restless Leg Syndrome is due to an underlying disorder, finding and treating the cause is the most appropriate goal.  Symptomatic treatment consists of using benzodiazepines (e.g. clonazepam) if symptoms are mild; levadopa or opiods (e.g. codeine) if symptoms are more severe, or anticonvulsants (e.g. carbamazepine), which are helpful for some patients. [7, 8]  It should be noted that all these medications have side effects and are only palliative at best.  In fact, the medical treatment of Restless Leg Syndrome using these medications does not address the underlying cause of the condition, nor do they work to support the body to perform in a more healthful way. Restless Leg Syndrome as a condition does not result from suboptimal levels of the above drugs; it is a condition warranting deeper investigation.     Supplements helpful for Restless Leg Syndrome   Folic Acid Folate is a term that refers to different forms of folic acid.  Some foods, such as dark leafy green vegetables, are a great source of folic acid, while other foods are fortified with folic acid.  In order for appropriate absorption, folic acid needs to go through a metabolic process which occurs at a pH of about 6-7. [9]  In addition, folate has a very synergistic relationship with vitamin B12, as many metabolic reactions and processes in the body are dependent on these cofactors. For example, proper function of nerves and nerve conduction are directly related to these two nutrients.  In fact, a primary sign of B-12 and folate deficiency is impaired sensations in the limbs.   While not exclusively singled out as the cause of Restless Leg Syndrome, inadequate intake of these nutrients may predispose one to this condition.  In a study concerning 6 women aged 31- 70 with various neurological disorders including restless leg syndrome, improvement in their symptoms could be attributed to folic acid supplementation.  This study suggests restless leg syndrome could be one of the main clinical presentations of a folic acid deficiency. [10]  Researching examining folic and iron deficiency in pregnant women also provides evidence that low levels of each of these nutrients may be a contributing factor in Restless Leg Syndrome. [11]   Magnesium Magnesium, an important and abundant mineral in the body, plays a positive role in Restless Leg Syndrome.  Magnesium is shown to contribute to over 300 metabolic reactions in the body, including energy production and protein and carbohydrate metabolism. [12]  Magnesium also plays a role in nerve conduction, especially those concerning muscle function.  Magnesium acts as a mild muscle relaxant, and may serve to relax the muscles of the limbs, ensuring that proper levels of rest occurs during periods of sleep.   Although both low and high levels of magnesium have been reported in those with RSL, supplementation seems to help with symptoms.  A study involving 10 subjects suffering from insomnia due to restless leg syndrome showed an improvement in sleep and Restless Leg Syndrome symptoms after supplementation with magnesium. [13, 14]  Magnesium is necessary to maintain the electrical potentials of nerves and muscles, and for the transmission of these impulses across the neuromuscular junction.   Iron Iron is the most important transitional metal in the body, since it is involved in several metabolic processes, such as DNA synthesis and energy production.  This process is related to its ability as an electron donor/acceptor and oxygen transporter. [15]  While a deficiency can cause anemia, an excess can cause hemochromatosis and thus tight regulation is important for proper function on many levels.  Deficiency can have an effect on the central nervous system and there are implications that low levels of iron can contribute to Restless Leg Syndrome. [16]   Restless Leg Syndrome is children may have a direct connection to iron deficiency.  A study completed by the Mayo Clinic involving 538 children with sleep disorders (23 with diagnosed Restless Leg Syndrome), showed a commonality of low blood iron levels.  In addition, research done with pregnant women shows that low iron levels may be a contributing factor to the Restless Leg Syndrome that is commonly experienced. [17]   Kava Kava (Piper methysticum) Kava has been traditionally used as a ceremonial herb as early as the late 1600's. Today it is known for its uses in anxiety disorders, stress, insomnia, and restlessness, musculoskeletal pain and more.  The herb's pharmacological activity has mainly been attributed to components called kava-lactones.   Due to its sedative effects, it has been shown to improve sleep quality, making it a good option for those that suffer from restless leg syndrome as an obstacle to sleep. Some research suggests that the sedative effects may be due to an increase in GABA binding sites, and that it can produce local muscle paralysis by mechanisms similar to cocaine. [18, 19]  Furthermore, the produced muscle sedation does not effect respiration. [20]     Learn More About Restless Leg Syndrome Introduction to Restless Leg Syndrome Restless Leg Syndrome Treatment Products helpful for Restless Leg Syndrome Go Back Learn More

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