1
Merck Index, 12th ed. Whitehouse
Station: Merck Research
Laboratories, 1996.
2 Parker SP. ed.
McGaw Hill Dictionary of
Chemistry. New York: McGraw-Hill
Book Company 1984.
3 Menendez R,
Arruzazabala L, Mas R, et al.
Cholesterol-lowering effect of
policosanol on rabbits with
hypercholesterolaemia induced by a
wheat starch-casein diet. Br J
Nutr 1997;77:923-32.
4 Menendez R,
Fernandez SI, Del Rio A, et al.
Policosanol inhibits cholesterol
biosynthesis and enhances low
density lipoprotein processing in
cultured human fibroblasts. Biol
Res 1994;27:199-203.
5 Arruzazabala ML,
Mas R, Molina V, et al. Effect of
policosanol on platelet
aggregation in type II
hypercholesterolemic patients. Int
J Tissue React 1998;20:119-24.
6 Arruzazabala ML,
Valdes S, Mas R, et al. Effect of
policosanol successive dose
increases on platelet aggregation
in healthy volunteers. Pharmacol
Res 1996;34:181-5.
7 Arruzazabala ML,
Valdes S, Mas R, et al.
Comparative study of policosanol,
aspirin and the combination
therapy policosanol-aspirin on
platelet aggregation in healthy
volunteers. Pharmacol Res
1997;36:293-7.
8 Canetti M,
Moreira M, Mas R, et al. A
two-year study on the efficacy and
tolerability of policosanol in
patients with type II
hyperlipoproteinaemia. Int J Clin
Pharmacol Res 1995;15:159-65.
9 Pons P,
Rodriguez M, Robaina C, et al.
Effects of successive dose
increases of policosanol on the
lipid profile of patients with
type II hypercholesterolaemia and
tolerability to treatment. Int J
Clin Pharmacol Res 1994;14:27-33.
10 Torres O,
Agramonte AJ, Illnait J, et al.
Treatment of hypercholesterolemia
in NIDDM with policosanol.
Diabetes Care 1995;18:393-7.
11 Fernandez JC,
Mas R, Castano G, et al.
Comparison of the efficacy, safety
and tolerability of policosanol
versus fluvastatin in elderly
hypercholesterolaemic women. Clin
Drug Invest. 2001;21:103-113.
12 Ortensi G,
Gladstein J, Valli H, Tesone PA.
Comparative study of policosanol
versus simvastatin in elderly
patients with
hypercholesterolemia. Cur Ther Res
1997;58:390-401.
13 Castano G, Mas
R, Roca J, et al. A double-blind,
placebo-controlled study of the
effects of policosanol in patients
with intermittent claudication.
Angiology 1999;50:123-30.
14 Batista J,
Stusser R, Saez F, Perez B. Effect
of policosanol on hyperlipidemia
and coronary heart disease in
middle-aged patients. A 14-month
pilot study. Int J Clin Pharmacol
Ther 1996;34:134-7. 13 Ibid
15 Aleman CL, et
al. Carcinogenicity of policosanol
in mice: an 18-month study. Food
Chem Toxicol. Jul1995;33(7):573-8.
16 Mesa AR, et
al. Toxicity of policosanol in
beagle dogs: one-year study.
Toxicol Lett. Aug1994;73(2):81-90.
7 Ibid
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Policosanol Introduction