5-Hydroxytryptophan (5-HTP)
5-Hydroxytryptophan
(5-HTP), an amino acid precursor
to serotonin, may be beneficial in obese patients. Low levels
of serotonin (an important
neurotransmitter) have been linked
to carbohydrate craving and may
play a major role in the
development of obesity. Studies
have shown that 5-HTP
supplementation promotes weight
loss and decreases
carbohydrate intake by promoting
post-meal satiety (sensation of
fullness) and reduced appetite,
thereby leading to reduced food intake. [4,
5] One study shows that
5-HTP may help diabetics control
food intake and lose weight. [6]
Chromium
The trace mineral,
chromium, is often low in obese
patients. Chromium can be depleted
by eating a diet high in refined
sugar and white flour products, and
also by a lack of exercise. Chromium
regulates blood glucose levels,
decreases insulin resistance, aids
in weight loss, and
stabilizes the body's metabolism. [7,
8] Preliminary
studies have shown that chromium
picolinate supplementation results
in a reduction of body fat and
weight, and an increase in lean
body and muscle mass. [9,
10]
Ephedra (ma
huang)
The herb, ma huang
(ephedra) has a long tradition of
medical use in China. Ephedra and
the alkaloids, ephedrine and
pseudoephedrine, are sympathetic
nervous system stimulants that can
cause rapid heartbeat and high
blood pressure side effects. [11-14]
Ephedrine is contraindicated in
patients with heart disease, high
blood pressure, thyroid disease,
diabetes, or difficulty in
urination caused by prostate disease.
It is also contraindicated for patients taking
antihypertensive or antidepressant
drugs. [15]
Despite these
precautions, there have been many
studies of this herb's effect on
weight loss. Preliminary
findings report that ephedra increases the metabolism,
reduces body fat, and promotes
weight loss. [16-17] Other studies have
shown that the metabolic effects
of ephedra are enhanced by
combining with caffeine compounds
(methylxanthines). [18-21] However, ephedra-containing
products have been irresponsibly
abused and this abuse has lead to
an impending action
against their sale. [22,
23] ndividuals who choose to take ephedra-containing products should
do so under the supervision of a
health care professional.
Coenzyme Q10
(CoQ10)
Coenzyme Q10
(CoQ10) is an antioxidant that
boosts cellular energy production
in the mitochondria, the cell's
energy powerhouse. Supplementation
with CoQ10 has been reported to
help promote weight loss. [24]
Fiber
Supplements (Psyllium, Pectin,
Guar Gum, Chitosan)
A high-fiber diet
including the use of soluble and
insoluble fiber such as pectin
(fruit fiber), psyllium (natural
plant fiber), guar gum (Indian
cluster bea plant fiber), and
chitosan (derived from shellfish
chitin) may be effective for
weight loss. Numerous studies
suggest that fiber supplements may
reduce the number of calories and
fat absorbed by the body, help
to control glucose and insulin
effects, increase post-meal
satiety (sensation of fullness),
and decrease appetite. [25-29] Since chitin
may prevent fat
absorption, it should not be taken
together with other fat-soluble
nutrients.
Guggulipid (Commiphora
mukul)
Guggulipid, an
extract of the mukul myrrh tree (Commiphora
mukul) of India, has been used for
centuries to treat various
ailments including obesity and
infections. Supplementation with
guggulipid effectively lowers
blood cholesterol levels and
stimulates thyroid function, which
may help promote weight loss. [30]
Garcinia (hydroxycitrate)
Garcinia (hydroxycitrate),
an extract from the fruit of the
Garcinia cambogia tree of India,
has been found to help prevent fat
production and to suppress
appetite. [31-32]
Garcinia's effects have been
studied in animals, but human
studies are still preliminary to
validate these claims.
Conjugated
linoleic acid (CLA)
Conjugated linoleic acid (CLA)
helps transport dietary fat into
cells, where it is used to produce
energy. Supplementation with CLA
has been reported to help reduce
body fat and promote weight
loss. [33-35]
Bladderwrack (fucus
vesiculosus)
Bladderwrack (fucus
vesiculosus), a source of iodine
from seaweed, may be beneficial in
obese patients. Bladderwrack
supplementation stimulates thyroid
function, which may help promote
weight loss. [36] Since iodine toxicity problems are
possible, use bladderwrack
products which include the iodine
content on the label. [37]
Medium-chain
triglycerides (MCTs)
Medium-chain
triglycerides (MCTs), a special
type of fat derived from coconut
oil, may be beneficial in obese
patients. Studies have shown that
the substitution of MCT products
for long-chain fats may increase
metabolism and help promote
weight loss. [38-39] Due to the possibility of ketoacidosis, diabetics and
patients with liver disease and
should take MCTs under the
supervision of a health care
professional.