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Menopause Treatment

 

Until the results of the Women's Health Initiative (WHI) were reported in the July 2002 issue of the Journal of the American Medical Association (JAMA), hormone replacement therapy (HRT) was the main method for treating the symptoms of menopause. [4]  HRT, a combination of synthetic estrogen and progesterone (progestogen), was also believed to reduce the risk of conditions such as bowel cancer and osteoporosis.  However, during the course of the WHI study, which involved more than 16,000 women, researchers found significant increases in the risks of heart disease, stroke, blood clots, and breast cancer among the participants.  This caused a premature stoppage of the study. 

 

Researchers concluded that the harm from the use of synthetic hormones, far exceeded their benefits; which included, the reduction in bowel cancers, fractures, and menopausal symptoms.  Other large studies, including the Heart and Estrogen/Progestin Replacement Studies, have demonstrated similar risks as the WHI study. [5-7]  Given the risks associated with synthetic HRT, there has been a strong search by both the medical community and menopausal women to find safe and effective natural approaches to treating menopause.

 

 

Supplements helpful for Menopause

 

Calcium

Calcium, the body's most abundant mineral, is critical for bone health and strength.  Studies have shown that calcium supplementation helps to reduce the bone loss, and fractures, in menopausal women. [8-10]  Experts suggest that calcium citrate is the best form of calcium supplementation.  This may be, in large part, due to cal. citrate's enhanced absorption percentages within the body, and the decreased risk of kidney stone development. [11]

 

Magnesium

Magnesium aids calcium bone absorption and is as important as calcium in maintaining the integrity of developed bones, as well as in decreasing the risk of bone fractures. Studies show that low levels of magnesium are associated with decreased bone density and osteoporosis. [12-14]  Magnesium may also have a mild relaxing effect on muscles. [15]  Experts suggest that magnesium aspartate or magnesium citrate be used for supplementation because of its assimilation within the body. [16]  Magnesium should always be taken in a two-to-one ratio with calcium (take half as much magnesium as calcium).

 

Vitamin D

Vitamin D aids in calcium bone absorption and is an important nutrient for the maintenance of strong and healthy bones.  Studies show that low levels of vitamin D are associated with decreased bone density in menopausal women. [17-21]

 

Bioflavonoids and Vitamin C

Citrus bioflavonoids, such as hesperidin, in combination with vitamin C have been shown to improve many symptoms common in menopause.  Among these are; an improvement in venous strength and function, and relief from hot flashes. [22]  Studies also suggest that vitamin C supplementation may help maintain bone strength. [23-26]

 

Vitamin E

Vitamin E supplementation may be effective in relieving hot flashes and vaginal problems associated with menopause. [22]

 

Soy isoflavones

Soy isoflavones, such as genistein and daidzein, contain phytoestrogens that may relieve menopausal symptoms, including hot flashes and atrophic vaginitis.  They may also be equally effective in helping to maintain bone strength and providing a reduction the risk of heart disease and certain cancers (including breast cancer). [27-32]

 

Phytoestrogens produce a weak estrogenic action, similar to the natural estrogens found in the body.  Although numerous studies have found that soy may reduce the risk of breast cancer, some research suggest that soy isoflavones may stimulate estrogen-dependent breast cancer cells by raising estrogen levels. [33-35]  As a result, women with estrogen-positive breast cancer, or women at high risk for breast cancer, should take isoflavones only under the supervision of a health care practitioner.

 

Gamma oryzanol

Gamma oryzanol is a natural antioxidant found in grains and other foods.  This ester of ferulic acid is produced, largely, from rice bran oil.  Gamma oryzanol has been used medicinally by the Japanese for the treatment of menopause.  Several Japanese studies found that treatment with gamma oryzanol improved symptoms in menopausal women, including hot flashes, insomnia, and anxiety. [36-37]  Gamma oryzanol's beneficial effects appear to be due to its ability to reduce the secretion of leutinizing hormones (LH) by the pituitary, and by increasing excretion of endorphins by the hypothalamus gland.

 

Flaxseed oil

Flaxseed oil contains essential fatty acids that may reduce the risk of heart disease and regulate hormonal metabolism in menopausal women. [38-39]

 

Dong quai

Dong quai, or Angelica sinensis, is an Asian botanical that has been traditionally used to treat menstrual and menopausal symptoms.  Dong quai has weak estrogen-like activity that may be helpful in relieving hot flashes. [40]  However, some studies question dong quai's effectiveness in treating menopausal symptoms. [41-44]

 

Black cohosh

Black cohosh, or Cimicifuga racemosa, is a Native American botanical that has been used for centuries, in the treatment of both menstrual and menopausal symptoms. Remifemin®, a medication for the treatment of menopause, is a standardized extract of black cohosh that contains the phytoestrogen, formononetin.  Formononetin has demonstrated estrogen-like activity and has been used in Europe as an alternative to hormone replacement therapy.  Studies have shown that black cohosh improves symptoms in menopausal women, including hot flashes, insomnia, and anxiety. [40, 45-48]

 

Chasteberry

Chasteberry, or Vitex agnus-castus, is a Mediterranean botanical that has been studied in the natural treatments of premenstrual and menopausal symptoms. Chasteberry's beneficial effects appear to be due to its ability to stimulate the secretion of leutinizing hormone (LH) by the pituitary.  It may also produce a reduction in the excretion of follicle-stimulating hormone, or FSH. [40, 49-53]

 

Red clover

Red clover extract, containing the hytoestrogens biochanin A, fomonontein, genistein, and daidzein, has weak estrogenic effects that may be a potential treatment option for menopause sufferers.  Studies involving Promensil ®, a standardized extract of red clover, have reported mixed results in the treatment of various menopausal symptoms. [54, 55]

 

DHEA (Dehydroepiandroesterone)

DHEA, an adrenal hormone, may produce similar hormonal effects as hormone replacement therapies.  DHEA may also be effective in relieving menopausal symptoms, including; reduced libido, depression, decreased bone density, and increased cardiovascular risk. [56-62]  Studies show that low levels of DHEA are directly associated with greater symptoms of depression in menopausal and post-menopausal women. [56-58]

 

 

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