Calcium
Paradoxically,
calcium supplementation actually
decreases levels of calcium in the
urine of most patients. [6,
7] This is
thought to
be due to the formation of calcium
oxalate complexes in the GI tract
that are poorly absorbed. It has
been shown that calcium taken with
food is protective, but when taken away
from food, it can be problematic. [8,
9,
10] Therefore, when
taking calcium supplements, they
must be taken with food if the
goal is to reduce calcium oxalate
stone formation.
Vitamin B6
Pyridoxine is also
known as vitamin B6. There is a
large body of evidence supporting
the use of this vitamin for
prophylactic treatment of
kidney stones. Many years
ago, a deficiency of pyridoxine
was documented to be associated
with calcium oxalate stone
formation. [11] Since then, many studies have
examined the various treatment
approaches concerning patients
with recurrent calcium oxalate
stones. [12,
13,
14]
Patients with
idiopathic calcium oxalate stones
and mixed calcium oxalate/calcium
phosphate stones received vitamin
B6 supplementation for 4.5 to 6
years. [9] These patients showed a
significant decrease in stone
formation without major side
effects. Vitamin B6 is also useful
in the treatment of patients who
have the metabolic disorder,
primary hyperoxaluria, which can
cause nephrolithiais. [15,
16,
17]
Magnesium
Magnesium
supplementation has been observed
to have profound effects on
patients with recurrent kidney
stone formation. [18,
19,
20] It
appears that magnesium increases
the solubility of calcium oxalate,
thereby decreasing the incidence
of stone formation. One study
demonstrated that 85% of patients
in the magnesium treatment group
were stone free during the four
year treatment period. [18] The form of magnesium used in
these studies was magnesium
hydroxide.
Citrate
Citrate is an
important nutritional supplement
to consider for the prevention of
kidney stones. It has been shown
to be very effective against
calcium oxalate calculus
formation. [21] A
beneficial feature of citrate is that
it can be taken as a form of other
nutrients such as calcium citrate
or magnesium citrate.
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