[1] Online source: www.gslc.genetics.utah.edu
 

[2] Online source: www.yourgenesyourhealth.com
 

[3] Online source: www.healthnewsflash.com/conditions/down_syndrome
 

[4] Online source: www.MayoClinic.com
 

[5] Online source: National Down Syndrome Society: www.ndss.org
 

[6]  http://www.nichd.nih.gov/publications/pubs/downsyndrome/down.htm#TheOccurrence
 

[7]  ibid
 

[8] Napolitano G, Palka G, Grimaldi S, Giuliani C, Laglia G, Calabrese G, Satta MA, Neri G, Monaco F. Growth delay in Down syndrome and zinc sulphate supplementation. Am J Med Genet Suppl. 1990;7:63-5.
 

[9] Napolitano G, Palka G, Lio S, Bucci I, De Remigis P, Stuppia L, Monaco F, Is zinc deficiency a cause of subclinical hypothyroidism in Down syndrome?, Ann Genet. 1990;33(1):9-15
 

[10] Moriguchi T, Greiner RS, Salem N Jr. Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J of Neurochem 2000;75:2563-73.
 

[11] Wainwright P. Nutrition and behaviour: the role of n-3 fatty acids in cognitive function. Br J Nutr 2000;83:337-9.
 

[12]   Brooksbank BW, Martinez M, Balazs R, Altered composition of polyunsaturated fatty acyl groups in phosphoglycerides of Down's syndrome fetal brain. J Neurochem. 1985 Mar;44(3):869-74.
 

[13] Joulain, C., et al. (1994) Increased glutathione peroxidase activity in human blood mononuclear cells upon in vitro incubation with n-3 fatty acid. Biochem-Pharmrol. 47(8), 1315-1323.
 

[14] Gulesserian T, Seidl R, Hardmeier R, Cairns N, Lubec G. Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome. J Investig Med. 2001 Jan;49(1):41-6.
 

[15] Busciglio, J. & Yanker, B. (1995) Apoptosis and increased reactive oxygen in Down's syndrome neurons in vitro. Nature. 378, 776-778.
 

[16] Colombo MI, Girdardo E, Incarbone E, Conti R, Ricci BM, Maina D. Vitamin C in children with trisomy 21. Minerva Pediatr,1989;41(4):189-192
 

[17] Cengiz M, Seven M. Vitamin and mineral status in Down syndrome. Trace Elem Elec 2000;17(3):156-160
 

[18] PH Cartlidge and DA Curnock, Specific malabsorption of vitamin B12 in Down's syndrome, Archives of Disease in Childhood, Vol 61, 514-515
 

[19] Steen MT, Boddie AM, Fisher AJ, Macmahon W, Saxe D, Sullivan KM, Dembure PP, Elsas LJ. ,Neural-tube defects are associated with low concentrations of cobalamin (vitamin B12) in amniotic fluid., Prenat Diagn. 1998 Jun;18(6):545-55.
 

[20] Barkai G, Arbuzova S, Berkenstadt M, Heifetz S, Cuckle H,   Frequency of Down's syndrome and neural-tube defects in the same family.,  Lancet April 19, 2003;361:1331-35
 

[21] Bazelon M, Paine RS, Coeiw VA, et al. Reversal of hypotonia in infants with Down's syndrome by administration of 5-hydroxytryptophan. Lancet 1967;1:1130–3.
 

[22] Coleman M. Infantile spasms associated with 5-hydroxytryptophan administration in patients with Down's syndrome. Neurology 1971;21:911–9.