Curcumin
(turmeric)
Curcumin, the
yellow pigment of Curcuma longa
(turmeric), has been shown to
possess various
anti-inflammatory and antioxidant
effects (2-5). Curcumin may provide benefit in
the treatment of cystic
fibrosis. In a recent study,
researchers at Yale University
found that when curcumin was fed
to mice with the defective Cystic
Fibrosis protein, it resulted in
normal protein activity in the
respiratory and gastrointestinal
tracts (6).
Omega-3
Essential Fatty Acids (Fish Oil,
Flaxseed Oil)
Studies show that
supplementation with omega-3 fatty
acids such as fish oil and
flaxseed oil may have beneficial
effects for Cystic Fibrosis
patients, such as decreasing
inflammation and improving lung
function (7-9).
Antioxidants
(Beta-Carotene, Vitamin C, and
Vitamin E)
Antioxidant plasma
levels, including beta-carotene,
vitamin C, and vitamin E, are
often low in patients with
Cystic Fibrosis. This is due
to the impaired digestion and malabsorption in Cystic Fibrosis
patients, which reduces the
available supply of antioxidant
nutrients. Cystic Fibrosis
patient's suffer from difficulties
in fat
and cholesterol absorption and decreases vitamin E levels, since
vitamin E is transported through
the body by attaching to LDL
cholesterol. The amount of free
radicals are also increased
in Cystic Fibrosis patients.
This is caused by immune cell stimulation from
chronic disease and infectious
microorganisms (10).
Studies show that
supplementation with
beta-carotene, vitamin C, and
vitamin E may have beneficial
effects for Cystic Fibrosis
patients, such as boosting
antioxidant status and reducing
free radicals and oxidative stress
(10,
11).
Another study reports that
supplementation with vitamin C can
produce clinical improvement in
patients with chronic bronchitis
and respiratory infection (12).
Pancreatic
Digestive Enzymes
Due to pancreatic
insufficiency, Cystic Fibrosis
patients have difficulties with
fat digestion and food malabsorption. For Cystic Fibrosis
patients, supplementation with
pancreatic digestive enzymes has
been shown to aid digestion and
help the body to absorb and
utilize the food (13).
Probiotics
(Lactobacillus Acidophilus
and Bifidobacteria)
Probiotics
including lactobacillus
acidophilus (small bowel friendly
bacteria) and bifidobacteria
(large bowel friendly bacteria)
are nutritional supplements
containing the same beneficial
bacteria that are found in the
digestive tract. Since antibiotics
are used in Cystic Fibrosis
treatment and often
destroy friendly bacteria in the
intestinal tract, probiotic
supplementation is particularly
helpful for enhancing intestinal
tract immunity and insuring
healthy intestinal microflora. (14,
15).
N-acetyl
cysteine (NAC)
N-acetyl cysteine (NAC)
is an acetylated ester of the
amino acid cysteine, a precursor
for the synthesis of glutathione,
which acts as a detoxifying agent. Studies
show that supplementation with NAC
may have important beneficial
effects for Cystic Fibrosis
patients, such as reducing sticky
mucus secretion, improving lung
function, combating lung
infections, and decreasing
inflammation (16-20).
Bromelain
Bromelain, a
protein-digesting enzyme complex
derived from pineapple, has been
shown to have an antitussive
effect (cough suppression) and to
reduce the thickness of mucus (21).
Bromelain's mucolytic activity
reduces bronchial secretions,
making it effective in treating
respiratory tract diseases (22).
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