A Japanese study published in the December issue of Phytotherapy Research measured the effects of oral grape seed extract on cholasma in women. Cholasma is a hyperpigmentation condition that usually affects the face. It is an acquired condition of excess melanin production that can commonly occur in areas exposed to sun.
The treatment options for cholasma are limited and the desire for an effective treatment is great. The study evaluated the ability of grape seed extract, which is high in procyanidins, to reduce the melanin pigmentation. Women were given the treatment for 12 months, and the outcomes measures were clinical observation, L value (lightening index), melanin index, and size of area affected.
After six months of treatment 83% of the women showed improvements in the L value, melanin index, and clinical observation. There were no additional effects during the latter 6 months of treatment.
The authors concluded that grape seed extract is a valuable treatment for cholasma. It is effective as a 6-month treatment. Grape seed extract may serve as a preventative agent against further hyperpigmentation that can occur during the summer months.
Posted by Kristopher Foster on January 19, 2006 07:40 PM
