Isothiocyanate compounds found in cruciferous vegetables such as broccoli, brussels sprouts and cabbage, are known to have anticancer effects. However, GSTM1 and GSTT1 genes produce enzymes that block isothiocyanates.
The study, published in the Lancet (2005, vol. 366, no. 9496), investigated the effect of cruciferous vegetables on lung cancer after determining GSTM1 and GSTT1 genetic status. Researchers at the International Agency for Cancer Research in Lyon, France, determined the genetic status of 2,141 lung cancer patients and 2,168 controls. Cruciferous vegetable consumption was analyzed from food frequency questionnaires obtained from the participants.
Researchers found that individuals with both GSTM1 and GSTT1 genes inactivated and a high (once per week) intake of cruciferous vegetables had a 72 percent lower risk of lung cancer than those with a low (less than once per month) intake. Furthermore, individuals with a high intake and an inactive GSTM1 gene had a 33 percent lower risk of lung cancer compared to those with a low intake. Individuals with high intake and an inactive GSTT1 gene had a 37 percent lower risk of lung cancer compared to those with a low intake. However, a protective effect against lung cancer was not associated with a high intake of cruciferous vegetables in individuals with both genes active.
"These data provide strong evidence for a substantial protective effect of cruciferous vegetable consumption on lung cancer," the study authors conclude.
Posted by Kristopher Foster on May 6, 2006 06:09 PM
