Helicobacter pylori (H.pylor) is a bacteria associated with conditions of the stomach and intestines. Individuals who have been colonized by this bacteria can develop several condtions including low stomach acid, peptic ulcers, and gastric cancer. Now research published in the American Heart Journal finds the bacteria may also be associated with vascular disease, or blood vessel health.
Investigators in Italy conducted a review of all clinical trials that investigated the association between H.pylori infection and disease of the blood vessels. Previous research had often produced conflicting results and the authors saught clarification about this very important relationship.
The incidence of peptic ulcer disease and stomach cancer is increasing as is the incidence of H.pylori infection. The bacteria is very difficult to treat, often requiring three medications administered simultaneously for successful treatment.
After reviewing more than 13 studies one particular strain of H.pylori, CagA+, was associated with increased risk for vascular disease. Other strains showed no association. In the studies the virulent strain was associated with increased risk for coronary artery disease and stroke (due to vasculature damage in brain).
The authors stress that this relationship may be of great clinical importance because of the rising rates of H.pylori infection in the Western countries. They estimate that as much as 40% of the population could be affected by H.pylori.
Posted by Dr. Christina Gutierrez on July 31, 2006 12:34 PM
